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Body protective compound-157 enhances alkali-burn wound healing in vivo. Drug Design, Development and Therapy , 2015

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de Rothschild, Paris, France, 10 Neurology Department, Hpital Lariboisire, Paris, France, 11 Universit Paris Cit, Paris, France, 12 INSERM, U1144, Paris, France, 13 FHU NeuroVasc, Paris, France, 14 Department of Neurology, Foch Hospital, Versailles Saint-Quentin en Yvelines University, Suresnes, France, 15 Department of Diagnostic and Therapeutic Neuroradiology, Universit de Lorraine, CHRU-Nancy, Nancy, France, 16 Universit de Lorraine, INSERM 1254, IADI, Nancy, France Background and Aims: Time from symptom onset to puncture (TSOP) and time from puncture to reperfusion (TPTR) are associated with worse outcome in ischemic stroke patients treated with endovascular therapy (EVT) in the early window ( 6 h), where EVT may benefit patients with favorable imaging profiles is unknown (late window paradox)

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the inventors also surprisingly found inhibitory activity with certain embodiments of the invention where R 1 is methyl with dual positional substitutions (see e.g., compounds 2j, 2m, 2k, and 2l, Table 2)